Premature babies, who often develop jaundice because of an excess of bile pigment called bilirubin, can be saved from this dangerous condition by the use of fluorescent light.… The light alters the chemistry of bilirubin so it can be excreted with the bile. Exchange transfusion is the usual treatment when jaundice occurs but this drastic procedure carries a … risk of death. —Science News, June 17, 1967
Update Preemies aren’t the only babies at risk for jaundice. About 60 percent of full-term infants also develop the condition. Severe cases can cause brain damage if untreated. But today, some researchers warn that light therapy, now widely used, may not work for babies whose bilirubin levels are very high. And studies have begun to suggest a link between the therapy and certain childhood cancers (SN Online: 1/30/15). Though the risk of developing cancer is small, doctors should be cautious about prescribing the treatment, researchers wrote in 2016 in Pediatrics.
On June 18, 4-year-old Bentley Thomas Koch fatally shot himself in the face. A few weeks earlier, Harmony Warfield, age 7, was shot and killed by her 2-year-old cousin. And teens Shadi Najjar and Artem Ziberov, both on the eve of graduating from high school, died in a hail of gunfire. Stories like these of kids dying from gunshot wounds are devastating, but, sadly, they aren’t an anomaly.
The most comprehensive look at fatal and nonfatal firearm injuries among children in the United States makes that abundantly clear. Every day, roughly 19 children die or are medically treated in an emergency department for gun-inflicted wounds, a study published June 19 in Pediatrics finds.
The statistics, based on data from 2002 to 2014, are stark:
Nearly 1,300 children, from birth to age 17, die from gunshot wounds each year on average and another 5,790 kids are wounded; Of the deaths, 53 percent are homicides, 38 percent are suicides and 6 percent are accidents; Boys ages 13 to 17 make up the bulk of gunshot victims; Cause of death varies by race — African-Americans are overwhelmingly more likely to die from homicide than suicide; white kids are nearly three times as likely to die from suicide as from homicide; and for American Indian and Asian-American kids, it’s 50-50. But this study doesn’t just lay out the numbers. It starts to dig deeper into the whys. And those whys can have important implications, laying the framework for policies that could ultimately lead to a drop in the numbers.
For the numbers, Katherine Fowler, a behavioral scientist at the U.S. Centers for Disease Control and Prevention, and colleagues started with data from the National Vital Statistics System and the National Electronic Injury Surveillance System.
For the whys, her team looked at cases described in the National Violent Death Reporting System, or NVDRS. That let the researchers fill in details like where an incident took place and whether it involved multiple victims — for instance, a homicide followed by suicide or a multiple victim homicide. The database also includes demographic information about the shooter, evidence of alcohol or drugs at the time of death, and whether the incident was gang-related or involved a boyfriend or girlfriend or parents. Clues to whether relationship, financial or school issues were part of the problem also come to light, as does evidence of depression, anxiety, any previous suicide attempt, treatment for mental health problems and physical health problems. Notes about playing with a gun or thinking the gun was a toy, as well as hunting accidents are also included. This tally of circumstances led Fowler and colleagues to conclude that firearm homicides of younger children, up through age 12, often involve conflict between parents, intimate partners or among family. “This highlights how children can be caught in the cross fire in cases of domestic violence and points to the importance of addressing the intersection of these forms of violence,” she says.
The results also reveal something important about child suicides involving guns. “While mental health factors are important, the findings also show that firearm suicides were also frequently related to situational life stressors and relationship problems with an intimate partner, friend or family member,” Fowler notes.
It’s these kinds of details that can help researchers and lawmakers create more effective policies to prevent such tragic deaths and injuries. It’s worked in other cases. Statistics have shown that tweaks to laws regulating the times of day teens can drive lead to injury prevention. Ditto for access to free swimming lessons when it comes to stopping accidental drownings. But similar data on gun deaths and injuries and the effectiveness of policy to prevent them are harder to come by thanks to lack of funding and political support (SN: 5/14/16, p. 16).
Even so, “we know kids are killing themselves and others with guns,” says David Hemenway, a Harvard University economist and an expert in gun research. When it comes to combatting the problem, “the circumstances help narrow down the policy.”
Fowler says the findings “highlight the need for evidence-based solutions to address this public health problem.” She’s armed with a laundry list of potential policies that could have an impact on the whys of gun violence and make a dent in the stats. School counseling programs could help kids manage their emotions and develop skills to resolve problems in relationships and with peers, she says. Along with therapy, those programs could help to reduce suicidal behavior and youth violence. Street outreach programs may also reduce gang-related violence. Parents and pediatricians talking about storing guns safely — a policy touted by the American Academy of Pediatrics, but one that has met resistance in some states — is another option.
There’s another big need, too: more data.
Despite a better picture of what’s happening when kids get a hold of guns, the data are fragmentary and incomplete, says pediatrician Eliot Nelson of the University of Vermont Children’s Hospital in Burlington. For instance, information from the NVDRS was limited to 17 states, so the numbers aren’t nationally representative. Last year, the database was expanded to 42 states and could eventually be expanded to all 50, but that will take additional funding from Congress.
The way gun injury and death data are coded in databases is another issue. Many unintentional deaths, such as when a child accidentally shoots and kills a sibling or friend, are labeled homicides, Hemenway says. Such misclassifications make it more difficult to create a policy, he says. Take, for instance, encouraging parents to lock up guns in the house. Without correctly coded data to say that younger kids are more likely to be killed by a gun at home while older kids are more likely to be killed by guns at a friend’s house, it’s harder to know how to talk to parents. For parents of young kids, the message might be to lock up their own guns; for parents of older kids, it might be to inquire about guns at the homes of their children’s friends. “We don’t always know who best to target our message to,” Nelson says.
Studies such as Fowler’s are slowly filling in the gaps. But not fast enough for kids like Bentley, Harmony, Shadi and Artem. “We want to keep growing our knowledge to prevent problems,” Nelson says. But, he says, it’s hard to do when money and politics hamper research into the problem. Gun-related deaths ranks third as the leading cause of death in 1- to 17-year-olds in the United States. “Gun death in kids is such a common problem,” Nelson says. “We can’t continue to ignore it.”
In Carl Sagan’s 1985 sci-fi novel Contact, a radio astronomer battles naysayers and funding setbacks to persist in her audacious plan — scanning the skies for signals from aliens. Sagan had real-life inspiration for his book (and the 1997 movie of the same name): astronomer Jill Tarter, who spearheaded the search for extraterrestrial intelligence, or SETI, for decades.
In Sagan’s story, the protagonist, Ellie Arroway, detects mysterious chatter from the cosmos. Tarter had no such luck. But her story, told by journalist Sarah Scoles in Making Contact, still provides insights into what it means to be human in a vast universe potentially harboring other life. Tarter began her career as a typical radio astronomer, studying mainstream topics like stars and galaxies as a Ph.D. student. But after graduating in 1975, she began to focus on SETI, poring over data from radio telescopes, searching for unnatural blips that could be a sign of an intelligent civilization. SETI researchers typically focus on radio waves because those long wavelengths can travel through our galaxy’s dust without being absorbed. Writings about SETI are prone to dreamy romanticism, but Making Contact admirably steers clear of excessive sentimentality. As a child gaping at the stars, Tarter wondered if creatures in the heavens were looking in our direction. Of course, Scoles notes, plenty of kids have wondered the same thing. Though Tarter’s childhood musings might seem special in retrospect, they aren’t what make her stand out.
Instead, Scoles — who has clear affection for her subject — highlights Tarter’s tenacity. In the face of numerous obstacles, Tarter pushed the field forward, seemingly by force of will.
In a detailed portrait of how the science sausage gets made, the book follows Tarter as she faced numerous funding woes. The field of SETI, which has at various points in its history received money through NASA, is an easy target for funding cuts, with some politicians deriding it as a wasteful hunt for “little green men.” Tarter, like the fictional Arroway, fought with Congress for taxpayer dollars SETI received, then scrambled for cash from other sources to keep telescopes and other equipment in operation. Wealthy donors kept SETI afloat — and still do. To maximize their ability to accept funding, Tarter and other SETI pioneers founded the nonprofit SETI Institute, in Mountain View, Calif., in 1984. Throughout, Tarter somehow managed to maintain her passion for a long shot search.
Although it’s a compelling story, the book stumbles in a few places, mainly minor sloppiness with physics facts, which may bother the most astute readers. (Scoles writes, for example, “Light is the only way we can learn about the universe,” neglecting gravitational waves and neutrinos, both of which have revealed secrets of cosmic objects.)
Now retired, Tarter has lost her chance to follow in Arroway’s fictional footsteps — she will never find any alien communiqués. But even if astronomers never hear from E.T., Tarter sees benefits in the search: SETI is an opportunity to make humankind less selfish. Just the thought that other creatures might inhabit the universe can make human squabbles seem less significant.
A strange property of spider silk helps explain how the arachnids avoid twirling wildly at the end of their ropes.
Researchers from China and England harvested silk from two species of golden orb weaver spiders, Nephila edulis and Nephila pilipes, and tested it with a torsion pendulum. The device has a hanging weight that rotates clockwise or counterclockwise, twisting whatever fiber it hangs from. When a typical fiber is twisted, the weight spins back and forth around an equilibrium point, eventually returning to its original orientation. But unlike several fibers the scientists tested — copper wires, carbon fibers and even human hair — the spider silk deformed when twisted. That distortion changed the silk’s equilibrium point and cut down on the back-and-forth spinning, the scientists report in the July 3 Applied Physics Letters. Eventually, scientists might design spin-resistant ropes for mountain climbers, who, like spiders, should avoid doing the twist.
A new type of soft robot can go under the knife and make a full recovery in about a day.
Researchers fashioned a robotic hand, gripper and muscle from self-healing rubbery material. To test their robots’ resilience, the engineers sliced each with a scalpel, then put them in an oven. After cranking up the heat to 80° Celsius, baking the bots for 40 minutes, then cooling them to room temperature, the researchers found that all three bots’ cuts had completely closed up. Twenty-four hours later, the machines had regained at least 98 percent of their original strength and flexibility, the researchers report online August 16 in Science Robotics. Incisions broke bonds between two chemical ingredients that make up the material, furan and maleimide. At higher temperatures, these chemical compounds can also split up, as well as move around more easily. So as the researchers cooled the material, the compounds were able to re-bond with those on the other side of an incision. “This material could heal, in theory, an infinite number of times,” says study coauthor Bram Vanderborght, an engineer at Vrije University Brussels.
The work helps address a major limitation of squishy, flexible robots — which are better suited than their traditional, rigid counterparts for navigating rough terrain and handling fragile objects, but are vulnerable to punctures and tears. Self-healing machines could pave the way for creating more durable, reusable soft bots.
When quickly reheated in a microwave and then pierced, the picnic staple can explode with a loud bang in a shower of hot, rubbery shrapnel. But this blast is far more likely to make a hot mess than hurt your hearing, according to research presented December 6 at the Acoustical Society of America meeting in New Orleans.
That distinction isn’t as odd as it might sound. In a lawsuit, a man claimed to have suffered burns and hearing damage after a microwaved, hard-boiled egg exploded in his mouth at a restaurant. Researchers from Charles M. Salter Associates, Inc. in San Francisco called as expert witnesses couldn’t find scientific papers backing up the claim that an egg could burst with enough vigor to cause hearing loss — just a lot of YouTube videos documenting eggsplosions. So the researchers microwaved peeled hard-boiled eggs in water on high power for three minutes.
The eggs were “uncooperative,” study coauthor Anthony Nash said in a news conference. Some exploded in the microwave, while others wouldn’t explode at all. But of nearly 100 eggs tested, 28 exploded outside of the microwave after being poked with a meat thermometer. From 30 centimeters away, the sound pressure from those explosions ranged from 86 to 133 decibels.
The median sound pressure level recorded, 108 decibels, is about the same as that at an average rock concert. Continuous exposure to that noise level could damage hair cells inside ears that respond to sound. The National Institute for Occupational Safety and Health sets recommended exposure limits for sound pressures above 85 decibels, says William Murphy, a researcher at NIOSH who wasn’t part of the study. But those limits are based on daily exposure over years, he says. A burst egg’s boom, on the other hand, lasts just milliseconds — not long enough to do much harm. “The likelihood for hearing damage from a single exploding egg was very low,” Nash said.
The lawsuit was settled out of court before Nash and his colleagues conducted the second phase of the study – considering how sound hits your ears when it’s coming from inside your mouth. An in-mouth explosion might send slightly more sound pressure to the ears, Nash says, but still probably not enough to cause lasting damage as a one-time accident.
A peeled egg probably explodes when pockets of water trapped in the yolk become superheated — hotter than the boiling temperature of water without actually bubbling, Nash suggested. When disrupted, say by a fork or a tooth, the water pockets spontaneously boil, bursting through the squishy egg white and sending bits flying. (It’s the same phenomenon that can occasionally make microwaved coffee spurt out of the mug onto your clean work clothes.)
A bigger risk than the noise might be the heat. Nash and his colleagues measured the temperature of yolks in eggs that didn’t burst. Those temperatures were, on average, 12 degrees Celsius above the surrounding water bath, which was often close to boiling.
This year, gene therapy finally became a clinical reality. The U.S. Food and Drug Administration approved two personalized treatments that engineer a patient’s own immune system to hunt down and kill cancer cells. The treatments, the first gene therapies ever approved by the FDA, work in people with certain blood cancers, even patients whose cancers haven’t responded to other treatments.
Called CAR-T cell immunotherapy (for chimeric antigen receptor T cell), one is for kids and young adults with B cell acute lymphoblastic leukemia, or ALL, approved in August (SN Online: 8/30/17). The other is for adults with non-Hodgkin lymphoma, approved in October. Other CAR-T cell therapies are in testing, including a treatment for multiple myeloma. “It’s a completely different way of treating cancer,” says pediatric oncologist Stephan Grupp, who directs the Cancer Immunotherapy Program at the Children’s Hospital of Philadelphia. Grupp spearheaded the clinical trials of the newly approved ALL therapy, called Kymriah.
Researchers are developing many different versions of CAR-T cell therapies, but the basic premise is the same: Doctors remove a patient’s T cells (immune system cells that attack invaders) from a blood sample and genetically modify them to produce artificial proteins on their surfaces. Those proteins, called chimeric antigen receptors, recognize the cancer cells in the patient’s body. After the modified T cells make many copies of themselves in the lab, they’re unleashed in the patient’s bloodstream to find and kill cancer cells. CAR-T cell therapy is particularly exciting because it works well in people whose cancers haven’t responded to other available treatments, says Renier Brentjens, an oncologist at Memorial Sloan Kettering Cancer Center in New York City. Of the 63 kids and young adults treated in a clinical trial of Kymriah, 83 percent had their cancers go into remission within three months. Now that these therapies have been clinically approved, there’s been an “explosion of interest” in the approach, says Dario Campano, an immunopathologist at the National University Cancer Institute in Singapore. Going forward, he expects to see even more rapid progress in the technology. Fifteen years ago, Campana helped develop the chimeric antigen receptor that’s used in Kymriah today. For now, the treatments are approved for use only when other treatments have failed, but someday CAR-T cell therapy could be the first treatment doctors try, he says.
One drawback is the price. Kymriah costs $475,000 for a onetime treatment, according to Novartis, which makes Kymriah. The non-Hodgkin lymphoma treatment made by Gilead Sciences, called Yescarta, is listed at $373,000. The total price tag for treatment could be higher when the costs of dealing with side effects and complications are factored in.
The approach is approved only for blood cancers. Using CAR-T cell therapy on solid tumors will require finding ways to get the T cells past additional cellular roadblocks, Grupp says.
Have you fallen behind on your reading this year? Or maybe you’ve plowed through your must-reads and are ready for more. Science News has got you covered. Here are the staff’s picks for some of the best science books of 2017. Find detailed reviews from previous issues in the links below or in our Editors pick: Favorite books of 2017.
Against the Grain James C. Scott
Armed with the latest archaeological research, a political anthropologist argues that the rise of civilization came at a big cost. The initial switch from hunting and gathering to agricultural states brought poor diets, labor-intensive work, outbreaks of infectious diseases and other hardships (SN: 10/14/17, p. 28). Yale Univ., $26
The Great Quake Henry Fountain
Historical records and interviews with survivors flesh out this tale of how a massive earthquake in Alaska in 1964 provided geologists with key evidence needed to verify the theory of plate tectonics (SN: 9/16/17, p. 32). Crown, $28
Eclipse Frank Close
More than just a primer on the science of solar eclipses, this memoir chronicles a physicist’s lifetime fascination with the celestial phenomenon and introduces readers to the quirky world of eclipse chasers (SN: 5/13/17, p. 28). Oxford Univ., $21.95
Rise of the Necrofauna Britt Wray
Resurrecting woolly mammoths, passenger pigeons and other extinct creatures isn’t just a technological problem, as this book explains. “De-extinction” is also rife with ethical dilemmas (SN: 10/28/17, p. 28). Greystone Books, $26.95
Big Chicken Maryn McKenna
Antibiotics transformed chicken farming, to the detriment of the birds and of human health, a journalist contends. Widespread use of the drugs fueled the industrialization of poultry production and the rise of antibiotic-resistant bacteria (SN: 9/30/17, p. 30). National Geographic, $27
Inferior Angela Saini
A science writer makes a persuasive case that centuries of biased thinking and flawed scientific research have reinforced sexist stereotypes about women (SN: 9/2/17, p. 27). Beacon Press, $25.95
Caesar’s Last Breath Sam Kean
Through fun historical anecdotes and lesser-known backstories of scientific greats, this entertaining book profiles the chemical elements that make up the air we breathe and traces the history of Earth’s atmosphere (SN: 7/8/17 & 7/22/17, p. 38). Little, Brown and Co., $28
Cannibalism Bill Schutt
The grisly practice of eating your own kind turns out to be widespread in the animal kingdom, a zoologist explains in this captivating look at cannibalism (SN: 2/18/17, p. 29). Algonquin Books, $26.95
The Lost City of the Monkey God Douglas Preston
A journalist tags along on an archaeological expedition to search for the real-life remains of a mythological city in this rainforest adventure tale that morphs into a medical mystery (SN: 2/4/17, p. 28). Grand Central Publishing, $28
The Death and Life of the Great Lakes Dan Egan
Invasive species, urbanization and other threats have wreaked havoc on the Great Lakes, but this book still finds some glimmers of hope in the scientists who are making headway in resuscitating the ecosystem (SN: 3/18/17, p. 30). W.W. Norton & Co., $27.95
How to Tame a Fox Lee Alan Dugatkin and Lyudmila Trut
An experiment to replay animal domestication by selectively breeding wild silver foxes is lovingly retold, including by the researcher who has kept the project alive for nearly 60 years (SN: 5/13/17, p. 29). Univ. of Chicago, $26
Making Contact Sarah Scoles
In the face of numerous obstacles, Jill Tarter still managed to spearhead the search for extraterrestrial intelligence for decades, as this biography recounts (SN: 8/5/17, p. 26). Pegasus Books, $27.95
A Crack in Creation Jennifer A. Doudna and Samuel H. Sternberg
Two experts, including one of the pioneers of CRISPR/Cas9, discuss the science and ethics of gene editing. Houghton Mifflin Harcourt, $28
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Life expectancy in the United States has decreased for the second year in a row, the first back-to-back drops in more than 50 years, the U.S. Centers for Disease Control and Prevention reports.
In 2016, life expectancy at birth was 78.6 years for the U.S. population as a whole. That’s 0.1 year less than in 2015. For men, life expectancy decreased from 76.3 years in 2015 to 76.1 years in 2016, while in women it remained the same, at 81.1 years. The new data, from CDC’s National Center for Health Statistics, are published online December 21. Heart disease was the leading cause of death for 2016, followed by cancer, unintentional injuries such as drug overdoses and car crashes, chronic lower respiratory diseases including asthma, and stroke. Rounding out the top 10 causes of death were Alzheimer’s disease, diabetes, influenza and pneumonia, kidney disease and suicide.
The overall drop in life expectancy is largely a result of an uptick in the age-adjusted death rates for unintentional injuries, Alzheimer’s disease and suicide, the report’s authors say.
Fracking wells should not go to 11. Instead, turning down the volume — that is, of water pumped underground to help retrieve oil and gas — may reduce the number of earthquakes related to hydraulic fracturing.
The amount of water pumped into fracking wells is the No. 1 factor related to earthquake occurrence at Fox Creek, a large oil and gas production site in central Canada, researchers report January 19 in Science. An injection of 10,000 cubic meters of fluid or more at a well appears to trigger a quake. Fox Creek sits atop the Duvernay Formation, a sedimentary layer rich in oil and gas. Before December 2013, the area was earthquake-free. Since then, hundreds of earthquakes have shaken the region; most were below magnitude 4, but a magnitude 4.8 quake in 2016 temporarily shut down operations.
Previous investigations revealed that fracking well injections at the site were triggering earthquakes on an underlying fault system. But mysteries remained: For example, why didn’t the quakes didn’t start until almost three years after fracking activities began in 2010?
Ryan Schultz of the Alberta Geological Survey in Edmonton and his colleagues compared the timing and location of the earthquakes with fracking activity at 300 wells in the region.
An analysis of rates of injection, fluid pressure and fluid volume for the wells closest in proximity to the quakes revealed that, at this site, only volume was linked to the quakes. A previous study has linked the rate of wastewater disposal injections to seismic slip (SN: 7/11/15, p. 10). As for the three-year delay, the authors say, fracking well injections tend to increase in volume over time as operations mature. So once the injection volumes reached that 10,000-cubic- meter threshold, the earthquakes began.
